Jekyll & Hyde is a Broadway musical based on the novel, The Strange Case of Dr Jekyll and Mr Hyde by Robert Louis Stevenson. The original stage conception was by Steve Cuden and Frank Wildhorn. The music was composed by Wildhorn and the lyrics were written by Leslie Bricusse.

The show opened on Broadway on April 28, 1997. There were 44 preview performances starting on March 21. The show ran for 1,543 regular performances, closing on January 7, 2001 and is the longest-running show in the history of the Plymouth Theatre.

Despite the long run, the musical lost money in the end: more than $1.5 million.

The show has also been adapted into a film starring David Hasselhoff and Coleen Sexton. The film was directed by Don Roy King.